Scientists use stem cells to build personalized ELISA kits

Scientists use stem cells to build personalized ELISA kits

Scientists have been committed to using stem cells in the laboratory to build blood vessels, but the current bottleneck is that they cannot effectively produce enough blood vessels for clinical treatment.

A few days ago, scientists at Johns Hopkins University successfully induced stem cells into a network of new blood vessels and transplanted the blood vessels into mice. The stem cells are reprogrammed from ordinary cells, so the new technology is expected to personalize the blood vessels for patients, so that there is no immune rejection.

Researchers have made great progress in making blood vessels, and it is very feasible to reconstruct the microvascular network and use it for clinical treatment. This discovery is expected to help treat patients with diabetes complications due to burn ELISA kits and blood vessel damage due to other causes.

Other laboratories use chemical signals to make stem cells form a single type of cell, or produce a hodgepodge of multiple types of cells for further sorting.

In this latest study, the researchers used a process-based approach to create new blood vessels. They took a different approach and developed a new method by which scientists can induce stem cells to target only two types of cells necessary for neovascularization. The researchers said that the new method avoids the process of sorting the required types of cells among a large number of cells and mixing the two types of cells, making the angiogenesis process faster and more stable.

Another difference in this study is that adult stem cells from the spinal cord are not used, and the researchers used induced pluripotent stem cells to make blood vessels. Since pluripotent stem cells are reprogrammed from mature cells, this means that the resulting blood vessels are tailored for specific patients. The researchers said that human induced pluripotent stem cells can form many types of cells, the benefit is that their genetic background is the same.

During the experiment, the scientists cultivated stem cells on a scaffold made of a soft and soft material hydrogel. The hydrogel showed the attachment of chemical signaling molecules, which made the stem cells induced into tissues with a certain vascular network. The study is the first to use human pluripotent stem cells to build blood vessels on synthetic materials.

In order to study whether the hydrogel-infused blood vessel can work in vivo, ELISA kits were transplanted into mice. Two weeks later, the constructed blood vessel successfully integrated with the mouse's own blood vessel, and the hydrogel began to degrade and disappear as the scientist designed it. The researchers said that the blood vessel can survive and function in the body, which is an important advancement in the medical community.

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