3D printing ceramic micro system to promote microfluidic chip or human organ chip application

The on-chip lab-microfluidics technology (Microfluidics) integrates basic operational units such as sample preparation, reaction, separation, and detection in biological, chemical, and medical analysis processes onto a micron-scale chip to automate the entire analysis process. . Due to its great potential in the fields of biology, chemistry, medicine, etc., it has developed into a new research field of biology, chemistry, medicine, fluids, electronics, materials, machinery and other disciplines.

Organs-on-a-chip is an emerging cutting-edge interdisciplinary technology developed in recent years. It has witnessed the biological behavior of the body in an unprecedented way, in new drug discovery, disease mechanism and toxicity prediction. Other fields have important application prospects.

The Autonomous University of Madrid and ceramic 3D printing company Lithoz have jointly developed a complex 3D printed ceramic microsystem that can advance the development and application of chip labs and human chip organs. The development team said its 3D printed ceramic devices marked a breakthrough in biomedical science.

3D打印陶瓷微系统推进微流控芯片或人体器官芯片应用

Using Lithoz's CeraFab 7500 machine (a lithography-based additive manufacturing system), the ceramic material was mixed with a photosensitive resin in 3D, and the octagonal chip was printed, and the resin was removed by sintering to fuse the ceramic particles. Together become a solid piece. This step is important because it meets the biomedical performance requirements of the sealing material required by the chip (to prevent leakage of living materials).  

3D打印陶瓷微系统推进微流控芯片或人体器官芯片应用

According to researchers, this 3D printed ceramic chip shows the potential to use ceramic materials for biomedical applications because they have higher strength and better temperature resistance than glass or plastic.

3D打印陶瓷微系统推进微流控芯片或人体器官芯片应用

The 3D printed ceramic microsystem is one-shot, meaning it doesn't require any components and no component maintenance. As part of its structure, the composite microsystem incorporates a porous membrane that separates different levels of cell culture chambers, similar to the function of transwell.

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