People often say: "Calm down, otherwise you will have heart disease." This is for a certain reason. Chronic stress – such as stress from work, money or interpersonal relationships – may increase the risk of heart attack. Researchers at the current level have explained why chronic stress can harm the cardiovascular system by studying busy doctors and tired rodents. They suggested that the study be centered around immune cells entering the blood circulation. Epidemiological studies have shown that people who face many stresses, from those who survived natural disasters to those who work long hours, are more likely to develop atherosclerosis, a fatty plaque that accumulates in blood vessels. In addition to fat and cholesterol, plaques also contain immune cells that cause inflammation of the blood vessel wall - monocytes and neutrophils. When plaques fall off the walls of the blood vessels they accumulate, they cause more extreme blockages in other areas, causing a stroke or heart attack. By studying the impact of intensive care unit (ICU) shifts on medical staff, Harvard Medical School biologist Matthias Nahrendorf recently discovered that blood samples taken when doctors were most stressed had the highest levels of neutrophils and mononuclear cells. cell. In order to explore whether these white blood cells or white blood cells are the missing link between stress and atherosclerosis, he and his colleagues conducted mouse experiments. Nahrendorf's team exposed mice to stress for up to six weeks, including tilting their cages, rapidly alternating light and darkness, or periodically switching mice between isolated and crowded homes. . Stressed mice, like nervous doctors, have increased levels of neutrophils and monocytes in the blood compared to the control group. The researchers then focused on explaining "why the levels of immune cells are elevated." They already know that chronic stress increases the blood concentration of norepinephrine; Nahrendorf found that norepinephrine binds to a cell surface receptor protein called β3 on stem cells in the bone marrow. In turn, the chemical environment of the bone marrow changes, and the activity of white blood cells produced by stem cells increases. Nahrendorf said: "Because of the expansion of white blood cell production, you are prepared for danger. For example, in a battle, you may be injured, so stress awakens these immune cells. This explanation has some truth. But chronic should Exciting is a different story - no wound healing, no infection." Lynn Hedrick, a biologist at the Institute of Allergy and Immunology at the La Jolla Institute in San Diego, California, points out that the discovery will bring new drugs to help prevent cardiovascular disease. He said: "I think this gives us a direct indication that the beta 3 receptor is very important for regulating the stress-induced bone marrow response. If we can develop a drug that targets this receptor, this may be very high. Clinical relevance." Product categories of Kitchen Tools , we are specialized sellers for Silicone Kitchen Utensils, Cool Kitchen Gadgets, Stainless Steel Utensils, sells high-quality products of Best Kitchen Gadgets. ARC USA, focuses on kitchen supplies, gives you the best product experience, the best product service. Don't wait! Just buy it now! Kitchen Tools Best Kitchen Gadgets,Cool Kitchen Gadgets,Stainless Steel Utensils,Silicone Kitchen Utensils ARC Advanced Royal Champion , https://www.arcimportcorp.com
How does stress cause cardiovascular disease?